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Furthermore, EODF reduced MPTP-induced striatal dopamine depletion, increased phosphorylation of PI3K and Akt, and increased phosphorylation of ERK and CREB, further supporting the involvement of neurotrophic factors in the observed neuroprotection

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Up to know, the majority of established and newly synthesized GST inhibitors have been primarily tested for their cytotoxic effect in cancer cell lines and mouse xenograft models, showing promising activities